Scientific Program
Scientific Program
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| Time | Day 1: Thursday, 15 September, 2011 |
|---|---|
| 08:00 - 09:00 | Session I : Special Lecture History of therapeutic hypothermia Speaker : William Dalton Dietrich Chair : Nariyuki Hayashi Sponsored by Senko Medical Instrument Mfg.Co., Ltd. |
| 09:00 - 10:00 | Session II : Special Lecture Future of therapeutic hypothermia for cardiac arrest Speaker : Lance Becker Chair : Tsuyoshi Maekawa Sponsored by Medtronic Japan Co., Ltd |
| 10:00 - 11:00 | Refreshment Break and Poster Presentations |
| 11:00 - 12:00 | Session III : Special Lecture Therapeutic hyporthermia for infant Speakers : Seetha Shankaran Satoshi Ibara Makoto Nabetani Chair : Masanori Tamura Sponsored by Kawasumi Laboratories, Inc. |
| 12:00 - 13:30 | Luncheon Session I Wonderful cooling method for foods; Cells Alive System Speaker : Norio Owada Chair : Ken Nagao |
| 13:30 - 14:30 | Session IV : The greatest authorities in Japan Speaker : Nariyuki Hayashi Yorihiro Yamamoto Tsuyoshi Maekawa Ryo Noda Chair : William Dalton Dietrich |
| 14:30 - 15:30 | Session V : Featured Research Therapeutic hypothermia for stroke or bleeding Speakers : 【Key Lecture】 Stefan Schwab Kiwon Lee Hitoshi Kobata Chair : Youichi Katayama Sponsored by Asahi Kasei Corporation |
| 15:30 - 16:30 | Refreshment Break and Poster Presentations |
| 16:30 - 18:30 | Session VI : Symposium Cooling methods Speakers : Stephen Bernard Rainer Kollmar Yoshimasa Takeda Hideki Arimoto Mayuki Aibiki Taketomo Soga Chair: Jerry P. Nolan Kjetil Sunde Sponsored by EMCOOLS |
| Time | Day 2: Friday, 16 September, 2011 |
|---|---|
| 08:00 - 09:00 | Session VII : Special Lecture Physiology of therapeutic hypothermia Speakers : Jerry P. Nolan Robert W. Neumar Chair : Tadeusz Wieloch Sponsored by OMRON COLIN Co., Ltd. |
| 09:00 - 10:00 | Session VIII : Featured Research Therapeutic hypothermia for trauma (inclusive of brain injury) Speakers : Peter Andrews Samuel Tisherman Chair : Hitoshi Kobata Sponsored by IMI.Co.,Ltd and Medivance, Inc. |
| 10:00 - 11:00 | Refreshment Break and Poster Presentations |
| 11:00 - 12:00 | Session IX : Featured Research Therapeutic hypothermia and PCI Speakers : Karl B. Kern Shinichi Shirai Chair : Hiroshi Nonogi Sponsored by ZOLL Medical Corporation |
| 12:00 - 13:30 | Luncheon Session II Waon Therapy (soothing and warmth) Speaker : Chuwa Tei Chair : Ken Nagao Sponsored by Daiichi Sankyo Co., Ltd. |
| 13:30 - 14:30 | Session X : Best of the Best Oral abstract presentations 4 abstracts Chair: Yorihiro Yamamoto |
| 14:30 - 15:30 | Session XI : Topic Ongoing studies of hypothermia Speaker : David Erlinge Tetsuya Sakamoto Chair : Hans Friberg Sponsored by Philips Electronics Japan, Ltd |
| 15:30 - 16:30 | Refreshment Break and Poster Presentations |
| 16:30 - 19:00 | Session XII : Symposium Therapeutic hypothermia for cardiac arrest and prognostication Speakers : Kjetil Sunde David F. Gaieski Clifton W. Callaway Noritoshi Ito Hans Friberg Koichiro Shinozaki Asuka Kasai Chair: Lance Becker |
Key Topics
1. Optimal therapeutic hypothermia
1. Inclusion criteria of the patients (adult, child, infant or newborn)
1. Cardiac arrest
2. Head injury
3. Cerebral apoplexy (ischemic stroke, intracerebral haemorrhage,
subarachnoid haemorrhage, etc)
4. Acute coronary syndrome
2. Cooling methods
3. Onset
4. Target core temperature
5. Duration
6. Rewarming
2. Prognostication
Speakers
Mayuki Aibiki, MD, PhD. has been the Chairperson and Director of the Department of Emergency Medicine, Ehime University, Graduate School of Medicine in Japan since August 1st 2007. He has been investigating the physiological and pharmacological changes during hypothermia. His group’s achievements include finding that sympathetic activations and direct cardiac depressions occur simultaneously during hypothermia induced by surface cooling (CCM, 2000). His recent interests are in the mechanisms of differences in sympathetic nerve responses depending on the cooling method, and searching for better predictors for the neurological outcome in post-cardiac arrest patients (ICM, 2011).
Peter Andrews is Professor at the University of Edinburgh (from August 1, 2007) and works in the Centre for Clinical Brain Sciences. Research streams include; “Direct Brain Cooling” studies attracting external funding and public recognition of the importance of this work. Prof. Andrews is the Chief Investigator of the EUROTHERM3235Trial investigating the titrated use of hypothermia after traumatic brain injury in patients with raised intracranial pressure. Prof Andrews also leads a laboratory research programme studying inflammation after lateral fluid percussion brain injury and is section head for Neurological-Intensive Care (Europe) at Faculty Medicine 1000 (http://www.facultyof1000.com ).
Lance B. Becker, M.D., is Professor of Emergency Medicine and the Founder and Director of the Center for Resuscitation Science at the University of Pennsylvania. Dr. Becker's research interests extend across basic science studies, animal models, to human therapies and bioengineering. His studies have helped define cellular reperfusion injury, mitochondrial medicine, CPR quality, AED use, survival rates, racial disparities, emergency cardiopulmonary bypass methods, hypothermia physiology and anti-reperfusion injury strategies. He is an innovator, international leader in resuscitation, helped develop the Resuscitation Science Symposium and has been elected to the Institute of Medicine, one of the highest honors bestowed in biomedicine.
Associate Professor Stephen Bernard, MD, FACEM, FCICM is a Critical Care Physician at The Alfred Hospital and Director of Intensive Care at Knox Private Hospital in Victoria, Australia. He is also Medical Advisor to Ambulance Victoria.
His research interests include the use of therapeutic hypothermia for the treatment of neurological injury after resuscitation from out-of-hospital cardiac arrest and traumatic brain injury. He has published the results of a number of clinical trials in this area.
Clifton W. Callaway earned his MD in 1993, and his PhD in Neurosciences in 1992, both from the University of California in San Diego. He completed a residency in Emergency Medicine at the University of Pittsburgh in 1996. Dr. Callaway was appointed Associate Professor in 2004, and received Tenure in 2007. He is the Ronald D. Stewart Endowed Chair of Emergency Medicine Research. In 2009, he was appointed Vice-Chair of Emergency Medicine. Dr. Callaway has distinguished himself as an investigator and as a teacher of paramedics, medical students and physician in the field of resuscitation medicine.
W. Dalton Dietrich, Ph.D. is Professor of Neurological Surgery, Neurology and Cell Biology at the University of Miami Miller School of Medicine. Since 1997, he has been Scientific Director of The Miami Project to Cure Paralysis, a Center of Excellence at the University. Dr. Dietrich’s laboratory investigates clinically relevant animal models of brain and spinal cord injury with the goal of developing therapies targeting these devastating disorders. He has published over 250 peer reviewed journal articles. Dr. Dietrich serves as Deputy Editor of the Journal of Neurotrauma, and Editor-in-Chief of Therapeutic Hypothermia and Temperature Management.
David Erlinge is Professor in Cardiology at Lund University, Sweden. He received an MD in 1990 followed by a PhD at the same university. He has been a visiting research fellow at Cornell Univ. Med. Coll., New York, NY. His clinical speciality is invasive cardiology (PCI). In 2006 he received The Lars Werkö distinguished research fellowship and in 2008 he was appointed Professor in Cardiology at Lund University. His research is focused on acute coronary syndromes, hypothermia, cardioprotection and platelet function. He has written more than 110 original articles.
Hans Friberg is an associate professor of Anesthesiology and Intensive care at Lund University, Sweden, and a senior consultant in critical care at Skåne University Hospital, Lund. His research field is within cardiopulmonary resuscitation and postresuscitation care. He is the initiator of the Lund Coma Project, which has resulted in numerous publications on prognostication after cardiac arrest. He is the initiator of the Hypothermia Network and Registry, which has developed into the International Cardiac Arrest Registry (INTCAR) with more than 3000 registered patients across the world. He is the senior investigator of the ongoing TTM-trial, the first RCT to date comparing two different target temperatures (33ºC vs 36ºC). He is the European editor of Therapeutic Hypothermia and Temperature Management.
David F. Gaieski, MD, is Assistant Professor of Emergency Medicine at the University of Pennsylvania and Clinical Director of the Center for Resuscitation Science. His research interests are in early interventions in critical illness, including treatments for severe sepsis/septic shock; bundled treatment of post-cardiac arrest syndrome; and novel biomarkers in sepsis and post-arrest states. Dr. Gaieski is primary investigator (PI) on several sepsis and post-arrest outcomes studies and site PI for an NIH-funded, multi-center Post-Cardiac Arrest Consortium investigating multimodal predictors of survival after cardiac arrest. Recent publications have been appeared in Annals of Emergency Medicine, Critical Care Medicine, and Chest.
Nariyuki HAYASHI, M.D., D.S.Sc is Professor of Advanced Research Institute for Science and Humanities, Nihon University. He is the first president of this International Brain Hypothermia Symposium Meeting in 2004 in Tokyo. Dr Hayashi’s Critical Care Emergency Medical Center of Nihon University has investigated the clinical management method of brain hypothermia treatment since from 1990. He is the first person who recorded brain tissue temperature of human and found brain thermo-pooling phenomenon in severe brain injured person. He has published about fundamental principle of control of brain tissue temperature in book of Brain Hypothermia Treatment 2004. He is now interested in the mechanism and management method of human mind and intelligence.
Satoshi Ibara, M.D., Ph.D. is Director of Department of Neonatology, Perinatal Medical Center, Kagoshima City Hospital, Japan and Clinical Professor of Faculty of Medicine, Kagoshima University, Kagoshima, Japan. From 1984 to 1985, Dr. Ibara received research training as a research fellow at Division of Maternal and Fetal Medicine, Department of Obstetrics and Gynecology,
University of California Irvine (UCI), USA. From1990 to 1991, he was involved in the study of artificial placenta by using Extracorporeal Membrane Oxygenation (ECMO) as Visiting Assistant Professor, Department of Obstetrics and Gynecology, University California Irvine (UCI), USA. He is actively engaged in research of brain hypothermia, ECMO, Blood purification in NICU.
Noritoshi Ito earned his MD in 2001, and has been a director of Critical & Cardiovascular Care Unit, Senri Critical Care Medical Center, Osaka Saiseikai Senri Hospital since 2009. He has been also a specially appointed researcher, Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine since 2011. His clinical speciality is invasive cardiology (PCI) and post cardiac arrest interventions (PCAIs). His research is focused on acute coronary syndromes, coronary microcirculation, hypothermia, extracorporeal CPR and brain protection. He is a principal investigator of J-POP registry (Japan-Prediction of neurological Outcome in Patients with out-of-hospital cardiac arrest registry).
Asuka Kasai MD earned her MD in 2001 from Nihon University School of Medicine. She works in the Department of Emergency Care, Resuscitation and Emergency Cardiovascular Care, Surugadai Nihon University Hospital. Her research interest is investigation of therapeutic hypothermia for cardiac arrest and prognostication.
Karl B. Kern, MD is a Professor of Medicine and Chief of the Section of Cardiology at the University of Arizona. Dr. Kern is an active interventional cardiologist with his clinical practice based at the University of Arizona Sarver Heart Center, where he is a Co-Director. He has been Director of the Cardiac Catheterization Laboratories at the University Medical Center for 8 years, as well as Director of the Interventional Cardiology Fellowship over the same period. Dr. Kern is currently the Chair of the American Heart Association Cardiopulmonary, Critical Care, Perioperative, and Resuscitation Council. He is the Coordinator of the University of Arizona Sarver Heart Center Resuscitation Research Group and has published over 150 original peer-reviewed research reports, most in the field of resuscitation science. His current interest centers around improving long-term survival rates post cardiac arrest through aggressive post resuscitation care.
Hitoshi Kobata, MD, PhD is Vice-Director of Osaka Mishima Emergency Critical Care Center and Clinical Professor of the Department of Neurosurgery, Osaka Medical College. After graduated from Osaka Medical College in 1984, Dr. Kobata received his neurosurgical training at the college hospital and Kitano Medical Research Institute and Hospital. He joined Osaka Mishima Emergency Critical Care Center in 1999, where his clinical activity focused on neurosurgery of severe stroke and traumatic brain injury along with resuscitation of critically ill neurological patients. He served as the President of Annual Meeting of the Japanese Association of Brain Hypothermia in 2010.
Rainer Kollmar is assistant professor of Neurology and Vice-Chair of the Department of Neurology at the Friedrich-Alexander University Erlangen-Nuremberg, Germany. Prior to joining the University of Erlangen-Nuremberg in 2006, he received his training at the Department of Neurology in Heidelberg, Germany. He initiated several investigator initiated trials (IITs) in therapeutic hypothermia including focal cerebral ischemia and intracerebral hemorrhage. In basic science, he performed several animal studies under the principle of hypothermic neuroprotection. Currently, numerous studies are being done in volunteers and patients to define specific task in cooling. He is one of the main initiators and investigators of the Eurohyp-1 study, which will cover 1500 stroke patients all over Europe.
Kiwon Lee, M.D., F.A.C.P., F.A.H.A. is Assistant Professor of Neurology and Neurological Surgery at Columbia University College of Physicians & Surgeons, and is faculty neuro-intensivist of the Neurological Intensive Care Unit at Columbia Presbyterina Hospital in NYC. A graduate of Columbia University, he received training in stroke and critical care from Harvard Medical School - Massachusetts General Hospital and Brigham and Women’s Hospital in Boston. Dr. Lee has been invited to give hundreds of grand rounds, keynote addresses, and special lectures around the world and published numerous peer-reviewed articles. His active research is on hemodynamic optimization and multimodality brain monitoring, refractory vasospasm, and therapeutic hypothermia.
Dr. Nabetani is Chief Director of the Pediatric Department and Vice Director of the Medical Department of Yodogawa Christian Hospital. He researched about mechanism of hypothermia during hypoxic ischemic encephalopathy (HIE) at the laboratory of Prof. Yasuhiro Okada of Kobe University, investigating intracellular calcium and glucose metabolism. Currently, he is eagerly engaged in clinical research about hypothermia therapy for neonatal
Robert W. Neumar is an Associated Professor of Emergency Medicine and Associate Director of the Center for Resuscitation Science at the University of Pennsylvania School of Medicine. He is also the past Chair of the AHA ACLS Subcommittee, and served as a member of the ILCOR ALS Task Force during the development of the 2010 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science with Treatment Recommendations. Dr. Neumar’s research is focused on the molecular mechanisms of neuronal injury caused by brain ischemia. His laboratory has recently examined strategies to optimize the timing and duration of therapeutic hypothermia after cardiac arrest.
Ryo Noda, Professor, Ph., D. (med.), Osaka University of Arts, Osaka, Japan, graduated from the Osaka College of Music as a saxophonist. He pursued advanced music studies at Northwestern University, Evanston, Illinois and at the Bordeaux Conservatory, in France. Noda 's work as a composer was recognized in 1973 by SACEM Composition Prize. Recently, he is known for his successful new method of Musico-Kinetic Therapy blending of Physiology, Medicine and Music. He has studied the MKT method for 30 years after returning to Japan in 1986, and to demonstrate the effect of the Musico-Kinetic Therapy for consciousness disturbance at Ishikiriseiki Hospital in Osaka.
Jerry Nolan, FRCA, FCEM, FRCP, FFICM is a consultant in anaesthesia and intensive care medicine at the Royal United Hospital, Bath, UK and Honorary Senior Lecturer in the School of Postgraduate Medicine at the University of Bath. He trained at Bristol Medical School, qualifying in 1983. He undertook anaesthesia and critical care training in the UK in Plymouth, Bristol, Bath and Southampton, and at the Shock Trauma Center, Baltimore in the United States. Dr Nolan is Co-chairman of the International Liaison Committee on Resuscitation (ILCOR), Immediate Past Chairman of the Resuscitation Council (UK), a board member of the European Resuscitation Council (ERC) and is Editor-in-Chief of the journal Resuscitation. He was co-editor of the 2005 and 2010 International Consensus on Cardiopulmonary Resuscitation (CPR) Science with Treatment Recommendations and the lead editor for the 2010 ERC CPR Guidelines. Dr Nolan’s research interests are in airway management, CPR, therapeutic hypothermia, and life support course development.
Mr. Norio Owada, Japan, established ABI Co., Ltd. in February 1989, started to manufacture the freezer with Induction Magnetic Field, which succeeded to freeze fresh cream.
In June 2007, he was granted patent for Cells Alive System (CAS) technology which enabled to preserve original food freshness for long term.
Medical researchers asked to use CAS freezer for their R&D and good results of CAS cryopreserve have reported like ovary transplant, periodontal membrane preserve, iPS cell and blood preserves.
Remarkable achievements by CAS technology conducted him to the honor of receiving Yellow Decoration Award in June 2011 by Emperor of Japan.
Tetsuya Sakamoto, MD, PhD is Director of Trauma and Resuscitation Center, and Chairman of Emergency Medicine, Teikyo University School of Medicine since 2005. He graduated University of Tokyo School of Medicine in 1983, where he was trained in emergency medicine and critical care medicine. He is Chairman of Cardiopulmonary Resuscitation Committee in Japan Foundation for Emergency Medicine, Executive Director of Japan Resuscitation Council, Editorial Board Member of Joint Committee for JRC Guidelines 2010, Vice President of Japanese Society for Emergency Medicine and Director of Japanese Association for Acute Medicine. He is the chief investigator in the SAVE-J project.
Stefan Schwab is Professor of Neurology and Director and Chair of the Department of Neurology at the Friedrich-Alexander University Erlangen-Nuremberg, Germany.
Prior to joining the University of Erlangen-Nuremberg in 2006, he received his training at the Department of Neurology in Würzburg, Aachen, and Heidelberg Germany. He initiated several path breaking studies on decompressive surgery in MCA-infarction as well as on hypothermia in ischemic stroke.
Dr. Schwab’s special interest is stroke diagnostics and MRI, treatment strategies for severe cerebral ischemia as well as neuroprotection and regulation of blood flow and metabolism.
He is president of the German Neurocritical care society (DGNI) and his work was honoured with several national and international awards such as the Wallenberg Price of German Neurological Society and the Willis-Lecture from the Spanish Neurological Society.
Seetha Shankaran, MD is Professor of Pediatrics and Director of Neonatal Perinatal Medicine at Wayne State University. She is principal investigator of the first US trial of neurprotection with hypothermia for hypoxic ischemic encephalopathy (HIE) in term infants, performed in the NICHD Neonatal Research Network and published in NEJM in 2005. The 6-7 year Follow up of the trial participants has been completed. Dr Shankaran is currently involved in two additional studies of cooling for neonatal HIE, longer deeper cooling and cooling for infants who develop HIE between 6 and 24 hours of age.
Koichiro Shinozaki. MD. PhD. is Director of the Department of Emergency and Critical Care Medicine, Chiba Aaoba Municipal Hospital. He graduated from Chiba University School of Medicine in 2002 and joined the Department of Emergency and Critical Care Medicine of the same medical school. His professional areas are in critical care medicine and acute care surgery. His research interests are in critical illness, including bundled treatments for severe sepsis/septic shock; multiple organ failre; post-cardiac arrest syndrome and novel biomarkers in post-cardiac arrest states. His recent publications appeared in Ther Apher Dial, Contrib Nephrol, Resuscitation and Critical Care.
Shinichi Shirai, M.D. has been director of the Cardiovascular Division and chief physician in the coronary care unit of Kokura Memorial Hospital since August 2011. After 4-year internal medicine training, he started his cardiology and interventional cardiologist carrier at Kokura Memorial Hospital. His researches were focused on coronary intervention with hypothermia for the patients after cardiac arrest, and complex coronary intervention using drug eluting stent. From this year, he was assigned the chief in charge of valvular heart interventions for aortic stenosis and structural interventions, such as device occlusion for ASD and vulvuloplasty for mitral stenosis.
Taketomo Soga, MD is a Cardiologist and Critical Care Physician at Department of Cardiology, Cardiopulmonary Resuscitation and Emergency Cardiovascular Care, Surugadai Nihon University Hospital. His research interests include the use of therapeutic hypothermia for the treatment of neurological injury after resuscitation from out-of-hospital cardiac arrest, coronary revascularization, treatment for circulatory failure and post-cardiac care.
Kjetil Sunde, MD, PhD, FERC is a professor at the Surgical ICU, Department of Anaesthesiology, Division of Critical Care at Oslo University Hospital, Norway. His main research field is cardiopulmonary resuscitation (CPR) with special focus in quality of CPR, optimizing chain of survival, haemodynamic experimental pig studies, mechanical CPR, VF analysis, and post resuscitation care including therapeutic hypothermia, with more than 75 international peer-reviewed papers. He has been an invited speaker and visiting professor throughout the world. At the moment he is supervising 7 PhD students. He is chairing the Advanced Life Support (ALS) Group in the Norwegian Resuscitation Council and through his Co-chair position in the ALS Committee in the European Resuscitation Council (ERC), he was central in the 2010 ILCOR Consensus of Science and Treatment Recommendations Document and the 2010 ERC Guidelines.
Yoshimasa Takeda, MD, PhD is Associate Professor of Anesthesiology at Okayama University Medical School. His research interests are early intervention in brain ischemia. He developed a pharyngeal cooling system to initiate therapeutic hypothermia before recovery of spontaneous circulation and is conducting a clinical trial of pharyngeal cooling system in 19 emergency centers in Japan. In laboratory, Dr. Takeda observes the dynamic changes of membrane depolarization during ischemia using DC potential and NADH fluorescence imaging.
Dr. Chuwa Tei is Professor and Chair of the Department of Cardiovascular, Respiratory and Metabolic Medicine, Kagoshima University, Japan. He is, at present, President of the Japanese College of Cardiology, International President of Asian-Pacific Congress on Echocardiography (APCDE), and President of Japanese Society of Gender-Specific Medicine. He developed Myocardial Contrast Echo, and he is well known as the proponent of the Tei index. He also developed the Waon Therapy, an innovative therapy for heart failure, peripheral artery disease, etc.
Samuel A. Tisherman, MD, FACS, FCCM is Professor of Critical Care Medicine and Surgery, Associate Director of the Safar Center for Resuscitation Research at the University of Pittsburgh. He completed medical school, general surgery residency, and surgical critical care fellowship at the University of Pittsburgh. He is the Director of the Neurotrauma ICU and Director of the Surgical Critical Care and Acute Care Surgery Fellowships. Dr. Tisherman’s research has focused on novel approaches to management of severe hemorrhage and cardiac arrest. He has worked on development of Emergency Preservation and Resuscitation (EPR), utilizing hypothermia to “buy time” for resuscitative surgery, for which he plans a clinical trial.
Yorihiro Yamamoto, Ph.D. is a Professor of Biochemistry at Tokyo University of Technology and serves as a Dean of its Graduate School. He has been focusing on free radical chemistry, biology and medicine for more than 30 years. He detected lipid hydroperoxide in human plasma and proved it is formed by a free radical-induced oxidation. He was involved in the development of a free radical scavenger drug (edaravone) for acute brain infarction. He recently identified a coenzyme Q10 binding and transfer protein (saposin B) and is studying its physiological role. He promotes coenzyme Q10 as an anti-aging supplement.